Cancer cells have adapted to tolerate the oxidative stress resulting from increased metabolism, yet these reactive oxygen and nitrogen species (ROS/RNS) can damage biomolecules and organelles, normally activating cell death pathways. Through this project, we aim to examine how perturbations to ROS/RNS levels within the tumor microenvironment contribute to immunogenic cell death and will engineer protein-based approaches to leverage oxidative stress for anti-tumor immune responses.
|K. Dane Wittrup, Ph.D.
C. P. Dubbs Professor of Chemical Engineering and Bioengineering
Associate Director, Koch Institute for Integrative Cancer Research
Massachusetts Institute of Technology
500 Main Street,
Cambridge, MA 02139
Office Phone: 617-253-4578
Department of Chemical Engineering
Department of Biological Engineering
Koch Institute for Integrative Cancer Research