Spatiotemporal programming of oxidative stress within the tumor microenvironment

Cancer cells have adapted to tolerate the oxidative stress resulting from increased metabolism, yet these reactive oxygen and nitrogen species (ROS/RNS) can damage biomolecules and organelles, normally activating cell death pathways. Through this project, we aim to examine how perturbations to ROS/RNS levels within the tumor microenvironment contribute to immunogenic cell death and will engineer protein-based approaches to leverage oxidative stress for anti-tumor immune responses.