Pharmacokinetics and Biophysical Properties of Non-specific Antibodies

The successful development of therapeutic monoclonal antibodies depends heavily on the specificity of the antibody to its target antigen. Unfortunately, some antibodies are more prone to off-target or non-specific binding, thus reducing their therapeutic efficacy. This project investigates the source of this non-specificity. Through this work, we aim to identify and potentially re-engineer “sticky” antibody motifs to reduce off-target binding while maintaining high-levels of specificity for the target antigens.